The course presents a general and up-to-date introduction to computational molecular biology. Attendants will learn fundamental physics and biology through a doable science project using high-performance computing resources. The format follows the style of a workshop. The first part of the lecture introduces the scientific merits of computational simulations to study biomolecular mechanisms, basic physics concepts and knowledge for large-scale computing. In the second half of the workshop, attendants will collaboratively work on a science project under the lecturers’ guidance with a computer for each student. This one-day workshop is a result of collaboration between Quarknet, the Texas Learning and Computation Center (TLC2), and Professor Cheung's group at the University of Houston to impact high-school science education and undergraduate research experience in the Houston area. Attendants will learn how some problems in today's molecular biology are being solved by computational simulations and how the work performance can be drastically improved through powerful computers and well-optimized software. Attendants will use personal computers in the computer center to view and analyze their data, as well as produce movie files from simulations. Next workshop will be held on July 17th, 2009, Friday at PGH 200, Texas Learning and Computation Center The University of Houston